JOURNAL ARTICLE

Humoral and Cellular Immunity Induced by Adjuvanted and Standard Trivalent Influenza Vaccine in Older Nursing Home Residents.

  • Published In: Journal of Infectious Diseases, 2023, v. 228, n. 6. P. 704 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Smith, Carson L; Bednarchik, Beth; Aung, Htin; Wilk, Dennis J; Boxer, Rebecca S; Daddato, Andrea E; Wilson, Brigid M; Gravenstein, Stefan; Canaday, David H 3 of 3

Abstract

This article focuses on comparing the immunogenicity of adjuvanted trivalent inactivated influenza vaccine (aTIV) versus standard nonadjuvanted trivalent inactivated vaccine (TIV) in nursing home residents (NHR) during the 2016–2017 influenza season. The study found that both vaccines elicited similar humoral and cellular immune responses, but aTIV induced significantly higher antineuraminidase (anti-NA) antibody titers against the A/H3N2 influenza strain at 28 days postvaccination, which persisted up to six months. Cellular immunity and hemagglutinin inhibition (HAI) titers did not differ significantly between vaccine groups. These immunological findings may explain the greater clinical protection observed with aTIV in reducing hospitalizations and influenza outbreaks among NHR, supporting recommendations for enhanced influenza vaccines in older adults.

Additional Information

  • Source:Journal of Infectious Diseases. 2023/09, Vol. 228, Issue 6, p704
  • Document Type:Article
  • Subject Area:Public Health
  • Publication Date:2023
  • ISSN:0022-1899
  • DOI:10.1093/infdis/jiad071
  • Accession Number:172021675
  • Copyright Statement:Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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