Silicone breast implants and Lupus.

We read with interest the case reported by Mir et al. on the development of SLE 2 years following the implantation of silicone breast implants.[1] This is an outstanding case to illustrate the complex link between adjuvant and induction of autoimmunity that underpins the description of the ASIA syndrome.[2]-[4] The etiopathogenesis of SLE is not fully understood; however, it is believed to be due to a loss of tolerance of the immune system that leads to the production of various autoantibodies. Two of the patients had a personal history of autoimmunity and two a familial history of autoimmunity.[7] Previously, a classical latency period of several weeks was accepted for post-vaccination events, similarly to the time frame suggested for post-infectious autoimmunity (i.e. rheumatic fever). Immune-mediated disease flares or new-onset disease in 27 subjects following mRNA/DNA SARS-CoV-2 vaccination. [Extracted from the article]