JOURNAL ARTICLE

Clinical Value of lncRNA CASC19 in Myocardial Infarction and its Role in Myocardial Infarction-Induced Cardiomyocyte Apoptosis.

  • Published In: Angiology, 2026, v. 77, n. 1. P. 44 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Lan, Zhou; Liu, Pengye; Tuo, Peng; Gao, Yuguang; Zhao, Ling; Huang, Qingyu 3 of 3

Abstract

This article investigates the role of long non-coding RNA cancer susceptibility 19 (lncRNA CASC19) in myocardial infarction (MI), focusing on its effects on cardiomyocyte activity, apoptosis, and oxidative stress. CASC19 expression was found to be elevated in the serum of MI patients and in hypoxia-induced rat cardiomyocyte (H9c2) models, with downregulation of CASC19 promoting cell proliferation and reducing apoptosis and oxidative stress. The study identified microRNA-218-5p (miR-218-5p) as a direct target of CASC19, where inhibition of miR-218-5p reversed the protective effects of CASC19 silencing on cardiomyocytes. These findings suggest that CASC19 may serve as a diagnostic biomarker for MI and modulate cardiomyocyte survival by sponging miR-218-5p, highlighting its potential clinical relevance in MI management.

Additional Information

  • Source:Angiology. 2026/01, Vol. 77, Issue 1, p44
  • Document Type:Article
  • Subject Area:Science
  • Publication Date:2026
  • ISSN:0003-3197
  • DOI:10.1177/00033197241273348
  • Accession Number:190326164
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