Jaw1/LRMP is associated with the maintenance of Golgi ribbon structure.

This article focuses on the role of Jaw1/LRMP, a membrane protein localized to the endoplasmic reticulum and outer nuclear membrane, in maintaining the Golgi apparatus morphology in mouse melanoma B16F10 cells. Using siRNA-mediated Jaw1 depletion, the study demonstrates that loss of Jaw1 causes fragmentation and disorganization of the Golgi ribbon structure while preserving the stacked cis- and trans-Golgi mini-stacks, accompanied by altered localization of the Golgi-derived microtubule network marked by acetylated α-Tubulin. Despite Golgi fragmentation, Jaw1 depletion does not impair the glycosylation function of the Golgi. The findings suggest that Jaw1, as a Klarsicht/ANC-1/Syne/homology (KASH) protein within the linker of nucleoskeleton and cytoskeleton (LINC) complex, contributes to Golgi ribbon maintenance potentially through interactions with the microtubule network and motor proteins, and may influence centrosome positioning relevant to Golgi organization.