JOURNAL ARTICLE

Neurotoxicity study of copper oxide nanoparticles and the protective role of a probiotic (Lactobacillus acidophilus) in Swiss albino mice.

  • Published In: Toxicology & Industrial Health, 2025, v. 41, n. 7. P. 398 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Sharma, Manisha; Rajawat, Neelu Kanwar 3 of 3

Abstract

This article focuses on the neurotoxic effects of copper oxide nanoparticles (CuONPs) and the potential neuroprotective role of the probiotic Lactobacillus acidophilus. In an experimental study using Swiss albino mice, CuONP exposure caused significant behavioral deficits, reductions in key neurotransmitters (acetylcholinesterase, dopamine, serotonin), and histopathological brain damage indicative of neurotoxicity. Co-administration of Lactobacillus acidophilus mitigated these adverse effects, improving behavioral outcomes, neurotransmitter levels, and brain tissue integrity. The findings suggest that probiotics may offer a promising strategy to counteract CuONP-induced neurotoxicity, highlighting concerns about the health risks of engineered CuONPs and the importance of protective interventions.

Additional Information

  • Source:Toxicology & Industrial Health. 2025/07, Vol. 41, Issue 7, p398
  • Document Type:Article
  • Subject Area:Science
  • Publication Date:2025
  • ISSN:0748-2337
  • DOI:10.1177/07482337251350165
  • Accession Number:186246015
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