JOURNAL ARTICLE

A case of biologic-resistant hand dermatitis demonstrates dual T2/T17 transcriptomic abnormalities and responds to Janus kinase inhibition.

  • Published In: British Journal of Dermatology, 2025, v. 192, n. 4. P. 743 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Taylor, Mark A; Yuan, Michelle; WANG, Sijia; North, Jeffrey P; Cheng, Jeffrey B; Cho, Raymond J 3 of 3

Abstract

The article discusses a case study of a 65-year-old female patient with biologic-resistant hand dermatitis (HD) showing features of both atopic dermatitis (AD) and plaque psoriasis (PP). The patient did not respond to traditional treatments but showed significant improvement with Janus kinase inhibition using ruxolitinib. Transcriptomic analysis revealed abnormalities in T2 and T17 pathways, suggesting broader immunological activation in the patient. The study highlights the potential of using cell-type-specific biomarkers to guide treatment decisions and the limitations of rigid disease classifications in dermatology. [Extracted from the article]

Additional Information

  • Source:British Journal of Dermatology. 2025/04, Vol. 192, Issue 4, p743
  • Document Type:Article
  • Subject Area:Science
  • Publication Date:2025
  • ISSN:0007-0963
  • DOI:10.1093/bjd/ljae430
  • Accession Number:183987634
  • Copyright Statement:Copyright of British Journal of Dermatology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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