Researchers at Imperial College London Report New Data on Science (Human brain changes after first psilocybin use).

This article focuses on a study conducted by Imperial College London investigating the effects of a single high dose (25 mg) of psilocybin on brain function and structure in 28 healthy, psychedelic-naive participants. Using electroencephalography (EEG), magnetic resonance imaging (MRI), and diffusion tensor imaging (DTI), the research found anatomical and functional brain changes from one hour to one month post-dosing, including decreased axial diffusivity in prefrontal-subcortical tracts and changes in brain network modularity. Psychological benefits such as increased cognitive flexibility, insight, and well-being were observed at one month, with EEG measures shortly after dosing predicting these improvements. No significant effects were noted with a 1 mg placebo dose, indicating these changes are specific to the higher psilocybin dose. [Extracted from the article]