Application of the CA330 cytokine adsorption cartridge for coupled plasma filtration adsorption therapy in severe acute pancreatitis-induced cytokine storm: A case report.

This article focuses on the application of coupled plasma filtration adsorption (CPFA) therapy using the CA330 cytokine adsorption cartridge to treat an 82-year-old male patient with severe acute pancreatitis complicated by a cytokine storm and renal dysfunction. The patient underwent two CPFA sessions, resulting in a significant reduction of cytokine levels such as interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10), and was successfully weaned off blood purification therapy after 43 hours. The study highlights that cytokine adsorption may reach saturation over time and notes complications including citrate accumulation and hypothermia during treatment, which were managed clinically. While CPFA remains controversial due to mixed results in prior trials, this case suggests potential benefits of using the CA330 cartridge in cytokine storm management, warranting further investigation to establish safety, efficacy, and optimal protocols.