Efficient Synthesis of Indolyl Benzo[b]Carbazoles via Surfactant‐Type Brønsted Acid‐Catalyzed Three‐Component Cyclization of Ortho‐Formylarylketones with Indoles.
Published In: European Journal of Organic Chemistry, 2025, v. 28, n. 15. P. 1 1 of 3
Database: Academic Search Ultimate 2 of 3
Authored By: Yang, Jun; Li, Tianxing; Jin, Hui; Zhang, Lixin 3 of 3
Abstract
The surfactant‐type Brønsted acid‐catalyzed multi‐component cascade reaction of ortho‐formylarylketones with indoles was investigated in an aqueous medium for the synthesis of indolyl benzo[b]carbazoles. The reaction was carried out in the presence of dodecylbenzenesulfonic acid, which was initiated by two consecutive nucleophilic additions of indoles to the aldehyde group of ortho‐formylarylketones, followed by a Friedel–Crafts‐type cyclization and dehydrative aromatization. This protocol afforded the desired products in good yields under mild conditions and demonstrated a broad substrate scope. [ABSTRACT FROM AUTHOR]
Additional Information
- Source:European Journal of Organic Chemistry. 2025/04, Vol. 28, Issue 15, p1
- Document Type:Article
- Subject Area:Science
- Publication Date:2025
- ISSN:1434-193X
- DOI:10.1002/ejoc.202401466
- Accession Number:185838983
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