JOURNAL ARTICLE

Chromosome shattering in cancer.

  • Published In: Science, 2025, v. 390, n. 6778. P. 1102 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Clarke, Stanley; Imieliński, Marcin 3 of 3

Abstract

Cancer cells often contain an abnormal number of chromosomes as a result of incorrect chromosome segregation during cell division. These fragments of genetic material can be encapsulated by a membrane, forming small nucleus-like structures called micronuclei. These structures often rupture, exposing chromatin (DNA and associated proteins) to the harsh environment of the cytoplasm, which can lead to large-scale DNA damage in a process called chromothripsis, or chromosome shattering and scrambling. On page 1156 of this issue, Krupina et al. (1) report that the cytoplasmic protein NEDD4-binding protein 2 (N4BP2) may be responsible for chromothripsis. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Science. 2025/12, Vol. 390, Issue 6778, p1102
  • Document Type:Article
  • Subject Area:Science
  • Publication Date:2025
  • ISSN:0036-8075
  • DOI:10.1126/science.aed1825
  • Accession Number:190202860
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