JOURNAL ARTICLE

Identification of 11-nor-∆8-Tetrahydrocannabinol-9-Carboxylic Acid in Postmortem Urine.

  • Published In: Journal of Analytical Toxicology, 2023, v. 47, n. 5. P. 481 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Crosby, Michele M; Truver, Michael T; Chronister, Chris W; Hoyer, Jennifer L; Kinsey, Amy M; Brogan, Sara C; Goldberger, Bruce A 3 of 3

Abstract

This article focuses on the emergence and forensic detection of ∆8-tetrahydrocannabinol (∆8-THC), an isomer of ∆9-tetrahydrocannabinol (∆9-THC), in postmortem casework. The Forensic Toxicology Laboratory at the University of Florida analyzed urine samples from approximately 900 decedents over four months, identifying ∆8-THC's primary metabolite, 11-nor-∆8-tetrahydrocannabinol-9-carboxylic acid (∆8-THC-acid), in 26 confirmed cases (13%), including six cases positive for ∆8-THC-acid only. Most decedents were White males with histories of drug or alcohol use, and poly-drug presence—including fentanyl, ethanol, cocaine, and methamphetamine—was common. The study highlights the need for forensic laboratories to adapt detection methods to monitor ∆8-THC and related isomers due to their increasing availability, psychoactive potential, and regulatory ambiguity.

Additional Information

  • Source:Journal of Analytical Toxicology. 2023/06, Vol. 47, Issue 5, p481
  • Document Type:Article
  • Subject Area:Social Sciences and Humanities
  • Publication Date:2023
  • ISSN:0146-4760
  • DOI:10.1093/jat/bkad023
  • Accession Number:163826846
  • Copyright Statement:Copyright of Journal of Analytical Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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