Health-related quality of life by race, ethnicity, and country of origin among cancer survivors.

This article focuses on a population-based study examining how health-related quality of life (HRQOL) among U.S. cancer survivors varies by self-reported race, ethnicity, and country of origin, adjusting for clinical and social determinants of health. Using data from 5,366 survivors across four Surveillance, Epidemiology, and End Results (SEER) cancer registries, the study identified four distinct HRQOL clusters—high, average, low, and very low—based on Patient-Reported Outcomes Measurement Information System (PROMIS) domains. Findings revealed that Caribbean, American Indian and Alaska Native, Cuban, Dominican, and Puerto Rican survivors were disproportionately represented in the very low HRQOL cluster compared to non-Hispanic White survivors, even after controlling for socioeconomic and clinical factors. The study underscores the importance of including detailed racial, ethnic, and country-of-origin data in HRQOL research to better identify at-risk groups and inform targeted interventions for improving survivorship outcomes.