JOURNAL ARTICLE

Swim-up versus density gradients for sperm preparation in infertile couples undergoing intrauterine insemination: a randomized clinical trial.

  • Published In: Human Reproduction, 2025, v. 40, n. 5. P. 788 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Duong, Tuyen N D; Dang, Vinh Q; Le, Tien K; Vu, Anh T L; Nguyen, Duy L; Pham, Toan D; Nguyen, Mai T; Nguyen, Phuong T M; Vo, Tuan M; Nguyen, Chau T H; Le, Phuong T B; Le, Anh H; Tran, Cam T; Mol, Ben W; Vuong, Lan N; Ho, Tuong M 3 of 3

Abstract

This article reports on a randomized clinical trial comparing the effectiveness of swim-up (SU) and density gradients (DG) sperm preparation techniques in infertile couples undergoing intrauterine insemination (IUI), with live birth rate as the primary outcome. Conducted at two IVF centers in Vietnam, the study randomized 912 couples and found no statistically significant difference in live birth rates between SU (12.1%) and DG (15.7%) after the first IUI cycle. Secondary outcomes, including clinical pregnancy, ongoing pregnancy, and obstetric and neonatal results, were also comparable. The findings suggest that both SU and DG are viable sperm preparation methods for IUI, with the choice potentially guided by practical considerations such as processing time and ease of standardization rather than differences in clinical effectiveness.

Additional Information

  • Source:Human Reproduction. 2025/05, Vol. 40, Issue 5, p788
  • Document Type:Article
  • Subject Area:Technology
  • Publication Date:2025
  • ISSN:0268-1161
  • DOI:10.1093/humrep/deaf047
  • Accession Number:186419808
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