Validation of Fespixon in Postoperative Scar Cosmesis Using Quantitative Digital Photography Analysis.

This article focuses on evaluating the efficacy of Fespixon, a topical medicine containing extracts from Plectranthus amboinicus (PA-F4) and Centella asiatica (S1), for preventing and improving postoperative transverse skin incision scars. In a prospective, double-blind, placebo-controlled trial involving 46 patients, Fespixon-treated scar halves showed significant improvements in pigmentation, vascularity, pliability, height, itchiness, and patient satisfaction compared to placebo-treated halves. Objective quantitative analysis using a digital photography system measuring colorimetric (CIELAB and hue) and texture (contrast, homogeneity, correlation, entropy) parameters corroborated these findings, demonstrating accelerated scar maturation and improved texture on the Fespixon side. The study also validated the digital photography analysis system as a reliable, cost-effective tool for objective scar assessment in clinical practice.