Goldenseal's therapeutic uses

DEFINITION: Natural plant product used to treat specific health conditions.

• PRINCIPAL PROPOSED USES: None
• OTHER PROPOSED USES: Athlete’s foot, congestive heart failure, dyspepsia, heart arrhythmia, high blood pressure, high cholesterol, infectious diarrhea, irritable bowel syndrome, minor wounds, vaginal yeast infection, urinary tract infections, antimicrobial, anti-inflammatory, digestive support, respiratory health, skin health

Overview

Although goldenseal root is a very popular herb, it is taken almost entirely for the wrong reasons. Originally, it was used by Indigenous Americans as a dye and a treatment for skin disorders, digestive problems, liver disease, diarrhea, and eye irritations. European settlers learned of the herb from the Iroquois, among others, and quickly adopted goldenseal as a part of early colonial medical care.

In the early nineteenth century, herbalist Samuel Thompson created a wildly popular system of medicine that swept the country. Thompson spoke of goldenseal as a nearly magical cure for many conditions. His evangelism led to a dramatic upsurge in demand, followed by overcollection and decimation of the wild plant. Prices skyrocketed, but then collapsed when Thompsonianism faded away.

Goldenseal has experienced several more booms and busts, and it has been proposed as a natural treatment for several medical conditions. However, there remained a lack of double-blind, placebo-controlled trials proving goldenseal's efficiency, and more scientific study was necessary.

Therapeutic Dosages

When goldenseal is used as a topical treatment for minor skin wounds, a sufficient quantity of goldenseal cream, ointment, or powder should be applied to cover the wound. It is important to clean the wound at least once a day to prevent goldenseal particles from becoming trapped in the healing tissues.

For mouth sores and sore throats, goldenseal tincture is swished or gargled. Goldenseal may also be used as a strong tea for this purpose, made by boiling 0.5 to 1 gram in a cup of water. The herb has a bitter taste. Goldenseal tea is also used as a douche for vaginal yeast infections.

Therapeutic Uses

Goldenseal contains a substance called berberine that has been found to inhibit or kill many microorganisms, including fungi, protozoa, and bacteria. On this basis, contemporary herbalists often use goldenseal as a topical antibiotic for skin wounds and to treat viral mouth sores and superficial fungal infections, such as athlete’s foot. However, direct scientific evidence that goldenseal is effective for these purposes is still emerging. However, one study did appear to indicate positive benefits for berberine in treating methicillin-resistant Staphylococcus aureus infections. Based on its traditional uses and antimicrobial and anti-inflammatory properties, goldenseal has also been suggested to treat skin conditions such as rashes and eczema. However, more scientific study is necessary. 

Goldenseal is not likely to work as an oral antibiotic because the blood levels of berberine that can be achieved by taking goldenseal orally are far too low to matter. However, goldenseal could theoretically be beneficial in treating sore throats and diseases of the digestive tract, such as infectious diarrhea, because it can contact the affected area directly. Since berberine is concentrated in the bladder, goldenseal could be useful for bladder infections. Nonetheless, there is little confirmatory evidence that goldenseal is effective for these uses, mostly due to the poor design of the studies that investigated it.

Extremely weak evidence (far too weak to rely upon) suggests that goldenseal or berberine may be helpful for various heart-related conditions, including arrhythmias, congestive heart failure, high cholesterol, diabetes, and high blood pressure. Similarly, limited evidence hints that goldenseal could be helpful for conditions in which spasms of smooth muscle play a role, such as dyspepsia (nonspecific stomach distress) and irritable bowel syndrome, as well as various forms of pain caused by inflammation. Goldenseal's anti-inflammatory properties may also be beneficial for additional digestive and respiratory issues. However, more studies were needed. Further, preliminary research appeared to suggest goldenseal could stimulate digestive secretions, suggesting an additional benefit for digestive health.

Ironically, goldenseal’s most common uses are entirely inappropriate. Goldenseal is frequently combined with the herb echinacea to be taken as a “traditional immune booster” and “antibiotic” for the prevention and treatment of colds. However, as the noted herbalist Paul Bergner has pointed out, there are three things wrong with this packaging. First, there is no credible evidence that goldenseal increases immunity. Only one study weakly hints at an immune-strengthening effect. Second, colds are caused by viruses and do not respond to antibiotics, even if goldenseal were an effective systemic (whole-body) antibiotic, which it almost certainly is not. Third, goldenseal was never used traditionally for the common cold.

The other myth that has helped drive the sales of goldenseal is the widespread belief that it can block a positive drug screen. The origin of this false idea dates back to a work of fiction published in 1900 by a pharmacist and author named John Uri Lloyd. In Stringtown on the Pike: A Tale of Northernmost Kentucky (1900), a dead man is found to have traces of goldenseal in his stomach. In fact, he had taken goldenseal regularly as a digestive aid, but a toxicology expert mistakes the goldenseal for strychnine and deduces intentional murder.

This work of fiction sufficed to create a folkloric connection between goldenseal and drug testing. Although the goldenseal in the story actually made a drug test come out falsely positive, this has been turned around to become a belief that goldenseal can make urine drug screens come out negative.

Goldenseal has many traditional uses that continue to be explored through scientific study. However, additional double-blind, placebo-controlled trials on goldenseal are necessary to prove its efficacy in treating these conditions.

Safety Issues

Although no reports of severe adverse effects are attributed to using goldenseal, this herb has not undergone much safety testing. One study suggests that the topical use of goldenseal could cause photosensitivity (an increased tendency to react to sun exposure).

Goldenseal should not be used by pregnant women because the herb has been reported to cause uterine contractions. Additionally, berberine may increase levels of bilirubin and cause genetic damage. The last of these effects indicates that individuals with elevated bilirubin levels (jaundice) should also avoid using goldenseal. Safety in young children, nursing women, or those with severe liver or kidney disease is also not established.

Just as there are incorrect rumors regarding the benefits of goldenseal, there are popular but incorrect beliefs regarding its health risks. For example, it is often said that goldenseal can disrupt the normal bacteria of the intestines. However, there is no scientific evidence that this occurs. Another fallacy is that small overdoses of goldenseal are toxic, causing ulcerations of the stomach and other mucous membranes. This idea is based on a misunderstanding of old literature.

Some evidence suggests that goldenseal might interact with various medications by altering how they are metabolized in the liver. One study found that berberine impairs the metabolism of the drug cyclosporine, thereby raising its levels. This could potentially cause toxicity. It is essential, therefore, to speak with a physician before taking goldenseal with other medications.

Bibliography

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Paulson, Brittany, and Heather M. Trevino. "Goldenseal - Health Encyclopedia." University of Rochester Medical Center, www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=19&contentid=Goldenseal. Accessed 19 Dec. 2025.

Petre, Alina. "Goldenseal: Benefits, Dosage, Side Effects, and More." Healthline, 18 June 2020, www.healthline.com/health/goldenseal-cure-for-everything. Accessed 19 Dec. 2025.

Zhang, Y., et al. "Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine." Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 7, 2008, pp. 2559-65.