Each year, Science’s reporters and editors look forward to the Breakthrough of the Year, their choice of the most significant scientific discovery, development, or trend in the year.

Science has chosen single-cell analyses of gene activity through time as its 2018 Breakthrough of the Year, honoring a trifecta of methods that together are enabling researchers to determine, at the individual cell level, which genes are turned on and off as an early embryo develops. Read the full article.

Science has been at the center of important scientific discovery since its founding in 1880. Today, Science continues to publish important research across the sciences, with articles that consistently rank among the most cited in the world.

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