Fertile Grounds for COVID Vaccine Safety

EBM Focus - Volume 17, Issue 18

Reference: Obstet Gynecol. 2022 Jan 25 early online

Vaccination against SARS-CoV-2 is recommended for pregnant individuals and for those considering future pregnancy, but rates of vaccine uptake among pregnant patients remain less than 25% in the US. Recent cohort data suggest that mRNA COVID vaccines appear safe in terms of neonatal and infant outcomes, and emerging data on early pregnancy outcomes are reassuring. While most studies of early pregnancy outcomes rely on observational registry data that report only clinical pregnancy losses (without capturing chemical pregnancies), data from patients undergoing IVF are uniquely poised to capture unrecognized early pregnancy losses.

A retrospective cohort study compared outcomes in vaccinated and unvaccinated patients undergoing controlled ovarian hyperstimulation or single euploid frozen-thawed embryo transfer between February and September 2021‌ in a single academic center in New York. Data were extracted from medical records. Protocols varied but were typical of fertility treatments. Patients were considered vaccinated if they had received two doses of either the Pfizer or Moderna COVID vaccine at least 14 days prior to the start of medications for their IVF cycle. The primary outcome for the ovarian hyperstimulation cohort was fertilization rates; the primary outcome for the embryo transfer cohort was clinical pregnancy rate.

For patients who underwent controlled ovarian hyperstimulation, fertilization rates were similar among 222 vaccinated and 983 unvaccinated patients, with rates of 80.7% and 78.7% respectively, p=0.39. Similarly, adjusted analysis demonstrated no significant associations for number of eggs or mature oocytes retrieved or blastulation rate. Vaccinated patients had higher rates of euploid embryos (48.8%) compared to unvaccinated patients (42.5%), p=0.02.

For patients who underwent embryo transfer, rates of clinical pregnancy were similar among 214 vaccinated patients and 733 unvaccinated patients, with rates of 59.5% [52.7–66.3] and 63.7% [60.2–67.3] respectively, p=0.27. No significant differences were seen in rates of pregnancy, ongoing pregnancy, or biochemical pregnancy loss. Rates of clinical pregnancy loss were 18.0% in vaccinated and 12.0% in unvaccinated patients, p=0.08. In adjusted analyses, no significant associations were found between vaccination status and the odds of clinical pregnancy (adjusted odds ratio [aOR] 0.79, 95% CI 0.54–‌1.16) or any of the secondary outcomes including rates of clinical pregnancy loss (aOR 1.02, 95% CI 0.51–‌2.06). Sensitivity analyses using propensity-matched cohorts demonstrated similarly nonsignificant results and found no differences in outcomes comparing the Pfizer and Moderna vaccines to one another.

This study adds to a growing body (belly) of evidence demonstrating that the Pfizer and Moderna vaccines do not negatively impact reproductive potential. A notable benefit of this particular study is that all pregnancies could be tracked, which allows for the ability to detect differences in early pregnancy losses that may go unrecognized in other data sets primarily reflecting clinical pregnancies. The study appears appropriately powered based on the investigators assumptions and calculations, and the multiple analyses reinforce that there were no significant associations no matter how you slice it. These reassuring data, together with the known increased risks of maternal and fetal morbidity and mortality associated with COVID infection in pregnancy, should make the choice to get vaccinated more and more clear for patients who are pregnant or considering pregnancy.

For more information, see the topic COVID-19 and Pregnant Patients in DynaMed.

DynaMed EBM Focus Editorial Team

This EBM Focus was written by Katharine DeGeorge, MD, MS, Deputy Editor at DynaMed and Associate Professor of Family Medicine at the University of Virginia. Edited by Alan Ehrlich, MD, Executive Editor at DynaMed and Associate Professor in Family Medicine at the University of Massachusetts Medical School; Dan Randall, MD, Deputy Editor at DynaMed; Carina Brown, MD, Assistant Professor at Cone Health Family Medicine Residency; Nicole Jensen, MD, Family Physician at WholeHealth Medical; Vincent Lemaitre, PhD, Senior Medical Writer at DynaMed; and Sarah Hill, MSc, Associate Editor at DynaMed.